Adrenocortical Dysplasia Homolog (ACD) (C-Term) Peptide
ACD
Reactivité: Souris
Hôte: Synthetic
BP, WB
N° du produit ABIN972806
Aperçu rapide pour Adrenocortical Dysplasia Homolog (ACD) (C-Term) Peptide (ABIN972806)
Antigène
ACD
(Adrenocortical Dysplasia Homolog (ACD))
Origine
Souris
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Séquence
- PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Acd Antibody(ARP36813_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ACD (Adrenocortical Dysplasia Homolog (ACD))
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Sujet
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Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.
Alias Symbols: -
Protein Size: 416 -
Poids moléculaire
- 45 kDa
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ID gène
- 497652
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NCBI Accession
- NM_001012638, NP_001012656
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UniProt
- Q5EE38
Antigène
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